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June 2008 BioSciCon Team for Telecytopathology participated at BIO 2008 International Convention. San Diego, California, June 2008 with a poster in the Innovative Corridor. The title of the presentation is A tool for integration of cytology, HPV screening and telecytopathology. May 2008 An independent study using MarkPap test in cervical cancer screening has been performed in India by the Department of Pathology and the Department of Obstetrics and Gynecology of the All India Institute for Medical Sciences (AIMS), New Delhi, India The paper is entitled Cervical acid phosphatase detection: A guide to abnormal cells in cytology smear screening for cervical cancer. It is published in Indian Journal of Cytology, 25 (1),1-5, 2008. April 2008 The Global Academy for Women's Health Team participated with an abstract entitled Ask for women' opinion first on FASEB Experimental Biology, 2008. Today's Research: Tomorrow's Health. San Diego, California, April 5-9, 2008. November 2007 Drs Markovic participated on the 55th Annual Meeting of the American Society of Cytopathology held in Huston on November 2-6, 2007. They presented the results of the application of MarkPap technology and its prospective in telecytopathology. Please click here to download the abstract. (PDF format) May 2007 BioSciCon participated with a poster MarkPap Test and HPV vaccination in the Innovation Corridor at the BIO 2007 International Convention held in Boston, MA May 6-9, 2007. At the Larta Venture Forum 2007, BioSciCon had a business Power Point Presentation "BioSciCon presents MarkPap Technology" given by Mr.Michael Dailey. The Forum that was held on May 1 and 2, 2007 in San Francisco, CA, is a cumulative event of the NIH Commercialization Assistant Program, where the new achievements and prospective of MarkPap technology and BioSciCon national and global business opportunities for investment were presented. April 2007 BioSciCon participated at the Experimental Biology Meeting held in Washington DC, April 18 -May 2, 2007.
March 2007 During the course of the NIH Commercialization Assistance Program 2006/2007, BioSciCon presented its business opportunity at the Larta NIH-CAP Outcome Workshop, March 26-30 in Washington, DC. Dr. Olivera Markovic, Founder of BioSciCon was honored among entrepreneurs 2007 on the Women in Bio 5th Annual Dinner, "Innovation Without Borders" that was held in Washington DC on March 27, 2007. December 2006 Local, national and international citations for BioSciCon: BioSciCon at FITCI BioSciCon listed as a corporate partner in World Science October 2006 Dr. Nenad Markovic presented a poster entitled MarkPap(r) technology, a new business opportunity for the Mid-Atlantic biotechnology in the Innovation Corridor at the Mid-Atlantic 2006 BIO in Washington DC. September 2006 BioSciCon, as NIH/SBIR phase 2 grant recipient, was selected by the National Institutes of Health, Bethesda, MD to participate in 2006 NIH Commercialization Assistance Program, to foster commercialization of the MarkPap technology. Larta Institute from Los Angeles, CA was assigned to this program. April 2006 Drs. Markovic participated at the Annual Meeting of the American Association for Cancer Research (AACR). They presented the biomarker-based MarkPap Digital technology, which allows the MarkPap test to be performed in a small laboratory by low-trained technician with easy-to-use MarkPap Kit. Guided by marker-positivity, the technician selects suspicious microscopic fields and transmits the images in diagnostic centers for evaluation by professionals. The results could be returned within hours. The MarkPap Digital opens a prospective for cytological screening around the world. The same prospective for global cervical cancer control with MarkPap technology was presented at the Innovative Corridor, BIO 2006 Convention in Chicago, IL. March 2006 Drs. Markovic participated at the Annual Meeting of the American Federation for Clinical Research (AFCR), Clinical Research 2006, held in Washington, DC. They presented their results on the application of the MarkPap test on HPV positive specimens. Since MarkPap could detect HPV infected cells together with cytological signs of abnormality, it was discussed of exploring this test as a potential method for monitoring the success of the HPV vaccination. At the Clinical Research 2006, Drs. Markovic also announced the prospective of moving Pap test to be performed in doctor's offices, when the new MarkPap Digital will be developed. Drs. Markovic actively participated on the NIH/NCI organized 4th Early Detection Network Scientific Conference held in Philadelphia. They presented the principle and the pilot results of MarkPap biomarker-based telecytopathology.
From June through December 2005, BioSciCon started systematic research and development of its second generation product MarkPap® Digital in collaboration with New Hope Pharmaceuticals, Inc., Gaithersburg, MD; GT Vision, Inc., Hagerstown, MD and ComputerCraft, Inc., McLean, VA. Because of the presence of the biomarker (the hallmark of MarkPap technology), which is amenable for digital photography and image analysis, MarkPap test is qualified for telecytopathology. This is our new product MarkPap® Digital, a potential integrated device combining image acquisition, image delivery and image analysis modules. MarkPap® Digital will provide an opportunity the slides to be stained in one location and the images from the microscopic field to be transmitted into a center for evaluation. This practically means that a general laboratory technician (in a remote laboratory or a nurse in a doctor’s office) can stain a specimen using the MarkPap® kit and will look on the specimen under the microscope searching only for “red” cells (marker positive--abnormal cells). Then, he/she will capture images with a digital camera (mounted on the microscope) and will transmit them via Internet to the center with pathologist/cytotechnologist for evaluation. The result may be sent back electronically within hours. The development of another product MarkPap Self, which allows a woman
to take a specimen in the privacy of her home, is also in progress. Please
see November 2005 BioSciCon’ poster, “MarkPap System. Current status and prospective” was presented at the Annual Meeting of the American Society for Cytopathology in San Diego, CA in November, 2005 September 2005 BioSciCon web site is cited at and is linked with the World Science
web site: http://world-science.net/home/links.html July 2005 Read more about BioSciCon presentation on the Century Club Breakfast
at the Business Alliance George Masson Press Release of June 9, 2005 June 2005 Dr. Olivera Markovic and Dr. Nenad Markovic participated in the Convention
BIO 2005, held in Philadelphia, PA . They presented a poster in
the Innovative Corridor with co-authors Dr. Shelly Parr and Dr. Vojislav
Zizic. The abstract "MarkPap® technology for cervical cancer
control" can be found at: May 2005 On May 18, 2005, BioSciCon, Inc. Rockville, MD, received the prestigious SCORE "Small Business Client of the Year 2005 Award." This award was presented to Dr. Olivera and Dr. Nenad Markovic at the Annual SCORE Luncheon at the Wyndham Hotel in Washington, DC in the presence of SCORE Chapter 1 counselors, highest SBA officials and guests. BioSciCon was awarded in recognition of a highly successful company, and for its achievements in the development of new products for cervical cancer screening and prevention that will improve global healthcare and save women's lives. March 2005 BioSciCon is announcing the incorporation of a business development
arm: The mission of MarkPap, LLC is to commercialize the MarkPap® technology products. The LLC is accepting applications for new members and for the management team. If interested, please contact us at info@bioscicon.com. More information to follow. February 2005 News from BioSciCon Research and Development. BioSciCon is currently developing the MarkPap® Digital and the MarkPap® Self tests. MarkPap® Digital is the MarkPap® test combined with IT technology into a system for telecytopathology, based upon the biomarker. MarkPap® Digital is intended for low-resource countries, where a general technician can locally perform the simple MarkPap® test with the easy-to-use kit, make digital images of "marked" microscopic fields, and transmit them via internet for evaluation. This is a chance for women in remote parts of the world to have an affordable cervical cancer screening within hours. MarkPap® Self is also based on the same competitive advantage: The presence of the biomarker on abnormal cells. Since the biomarker is a chemical compound deposited inside the cytoplasm, it is not a subject of deterioration like cellular integrity/morphology. We have seen retained red biomarker even in parts of cytoplasm after cell disintegration. This is a basis of prospective use of MarkPap® test in vaginal specimens of self-obtained material (MarkPap® Self Test). This test could be particularly important for women who do not have access to doctor‚s offices, yet to have cervical cancer screening. We believe that MarkPap® technology should revive the cytological approach to cervical cancer screening and will provide to the rest of the world the same benefit that Pap test has given to the developed countries. MarkPap® technology is compatible with other technologies for cervical cancer screening. January 2005 We have recently completed three clinical trials. We compared a combination (marker+Pap) versus Pap alone, and found that the combination is superior for detection of true positive/abnormal specimens (up to 50%), for reduction of false-negatives (more than 50%), and has equivalent specificity with the control Pap test. The presence of the biomarker reduced the screening time from 6 min to 3 min per slide. A total of 2,000 subject/specimens were analyzed by subgroups including: low- risk general population, high-risk population, Pap smear control for MarkPap® smears, and ThinPrep Pap test control for liquid-based MarkPap® test.
December 2004 We are proud to announce the development of two new Research Sites in Los Angeles, CA, US. BioSciCon is also developing two new International Research Sites in New Delhi, India and in Belgrade, Serbia and Montenegro. More information will follow. October 2004 BioSciCon started exploring equity investment options with local angels and VCs in order to secure financing for the regulatory study required from FDA approval for the US market, and the commercialization of the technology. For more information please contact us at info@bioscicon.com, or call 1-301-610-9130. August 2004 BioSciCon is finalizing phase II/III clinical laboratory trials of the MarkPap® Test. We are currently searching for funding partnership (with individuals or other enterprises) that will assist us in bringing the new product to market. July 2004 A paper by Markovic O, Markovic N, and BioSciCon's Cervical Cancer Study
Group: Cervical acid phosphatase: A biomarker of cervical dysplasia and
potential surrogate endpoint for colposcopy appeared in Disease Markers 19(6), 279-286,
2003/2004. The abstract and the full text are available at: SBIR
and STTR Success Story for BioSciCon, Inc. June 2004 Markovic N., Markovic, O. Markovic, J. Sundeen, W. Smith Jr., Markovic S., BioSciCon Cervical Cancer Research Group*: Pap test and new biomarker-based technology for enhancing visibility of abnormal cells. 40th American Society for Clinical Oncology Annual Meeting, ASCO 2004, New Orleans, Louisiana. June 2004. J Clin Oncol, 22,9561,2004 www.asco.org/ac/1,1003,_12-002636-00_18-0026-00_19-003023,00.asp Drs. Nenad and Olivera Markovic participated in the 3rd Annual Early Detection Research Workshop (EDRN) organized from NCI, NIH in Bethesda, MD. They presented the development of MarkPap® Technology: From idea to commercial products. A biomarker-based, in vitro diagnostic device with potentials for cervical cancer screening. Book of Abstracts P-28, 2004. Drs. Olivera and Nenad Markovic participated in the 6th Annual SBIR/STTR Conference (June 23-24, 2004), organized by NIH in Bethesda, MD. They presented, as NIH SBIR 2nd phase awardees, their translational research entitled MarkPap® Technology for cervical cancer screening. Abstract Book p.7, 2004. May 2004 Dr. Lewis Townsend, President Contemporary Women's Health Associates, Bethesda MD and Drs. Olivera and Nenad Markovic attended the 52nd Annual Clinical Meeting of the American College of Obstetricians and Gynecologists in Philadelphia, PA. They presented the results on MarkPap® test reduces false-negative rates of cervical cancer screening. Townsend L, Markovic O, Markovic N, BioSciCon Cervical Cancer Study Group*, Obstetrics and Gynecology, Suppl. 103, (4), 81S,2004. *BioSciCon Cervical Cancer Study Group: Parr Shelley, MD., Ross Alan, MD., Sundeen James, MD., Rosser Rufus, MD., Gould Jed MD., Posarac Vladan, MD., Mrs. Linda Townsend. April 2004 Dr. James Sundeen, President Diagnostic Pathology Services, Clarksburg, MD and Medical Director Department of Pathology Prince George Hospital, Cheverly, MD attended the American Federation for Medical Research Clinical Research Meeting in Chicago, IL. He presented the results on Cervical Acid Phosphatase and PreservCyt®. Markovic N, Markovic O, Sundeen J, Smith W.Jr: Inv Medicine 52, Suppl 2,80,2004. Drs. Olivera and Nenad Markovic and Dr. Christopher Kemp, President, Kemp Technologies, Frederick, MD, attended the Experimental Biology Meeting 2004 in Washington, DC. They presented the results on: Could the enzyme-enhanced Pap test be automated? Markovic O, Markovic N, Kemp C: The FACEB J., Experimental Biology 2004, Abstracts Part 1, A200. Another poster, A cytoplasmic biomarker for liquid-based Pap was presented on the same meeting. Markovic O, Markovic N, Sundeen J., Smith W. Jr: The FACEB J. Experimental Biology 2004, Abstracts Part 1, A200. March, 2004 Dr. William Smith, Director, Department of Pathology, Suburban Hospital, Bethesda, MD attended the 2004 Biennial Meeting of the American Society for Colposcopy and Cervical Pathology held in Disney's Contemporary Resort, FL, March 2004. He presented the MarkPap® System for cervical cancer screening. Smith W Jr, Markovic N, Markovic O, Kumar A, Bermeyo, Mollish P, late Morris M: ASCCP 2004 Biennial Meeting. Book of Abstracts, p.340. February, 2004 Dr. Olivera Markovic attended the Symposium on Predictive Oncology & Intervention
Strategies in Nice, France, February 7-10, 2004. She presented the
following scientific communications: January, 2004 Cervical acid phosphatase: A new biomarker of cervical dysplasia appeared in Arch Oncol 11,243-247,2003. Authors Dr. Olivera Markovic and Dr. Nenad Markovic, with the members of the BioSciCon Cervical Cancer Study Group: Dr. James Sundeen, Dr. William Smith, Dr. Shelley Parr, Dr. Lewis Townsend, Dr. Allan Ross, Dr Rufus Rosser, and Dr. Jed Gould. |
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